Uchida, S., Ikari, N., Ohta, H., Niwa, M., Nonaka, G., Nishioka, I., and Ozaki, M. Inhibitory effects of condensed tannins on angiotensin converting enzyme. Sandy, OR: Eclectic Medical Publ, 1997. View abstract. Silica is a well-known ingredient that is going to have very nice overall effects on your hair, nails, and entire body. Am J Chin Med 2005;33(6):839-850. Estrovera's proprietary nonestrogen formula works with women's bodies to address menopausal concerns, taking the guesswork out of treating symptoms. Chinese Journal of Modern Developments in Traditional Medicine 1987;7(1):21-3, 4. Zhonghua Nei Ke.Za Zhi. [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. 2005;3(3):195-198. The constituent aloe-emodin has demonstrated anticancer(5)(6)(27) and anti-leishmanial(30) properties, and appeared to enhance effects of sorefenib(28) and cisplatin(29). Please see our Medical Disclaimer for more information. In lab animals, compounds in rhubarb called anthraquinones reduced pain, inflammation, and some tumors. [Clinical observation on patients with constipation using Rhubarb and Mangxiao]. It has large, undivided leaves, with succulent petioles (stalks). Gut 1993;34(8):1099-1101. (Cheema et al. View abstract. The leaf blades (but not the stalks) of rhubarb contain enough oxalic acid to cause poisoning. It also has additional products that target specific symptoms. Xiao-dong Z, An-yu W, Shao-feng W, and et al. Estrovera does seem like a reliable menopause relief product that women could take advantage of to handle their symptoms of menopause. The investigators suggest that increased perfusion of gastric mucosal blood flow, increased excretion of bacteria and toxins, and decreased permeability of intestinal mucous membranes contributed to the positive effects.20, Rhubarb appears to be a potential source of dietary fiber with a lipid-lowering effect. Song, H., Wang, Z., and Zhang, F. [Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it]. Tian, J., Du, H., Yang, H., Liu, X., and Li, Z. The active compound, called rhaponticin, was found to be beneficial to diabetics. Zhong.Xi.Yi.Jie.He.Za Zhi. Estroven claims that their Complete Multi-Symptom Menopause Relief can treat all symptoms of menopause, including hot flashes, night sweats, and sleep problems. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea). In the study, researchers examined the effectiveness of the rhubarb extract in treating 109 perimenopausal women with frequent hot flashes. The rhubarb that grows in the back yard is a different species, Rheum rhabarbarum. Menopause and insomnia: What is the link? Renggli, H. [Gingivitis-and plaque-inhibiting action of Pyralvex Berna and its components]. Contraindications have not been identified. Rhubarb is mainly used for digestive complaints such as diarrhea, constipation, heartburn, gastrointestinal (GI) bleeding, stomach pain, and preparation for GI diagnostic procedures. By Gerardo Gonzalez. Yokozawa, T., Fujioka, K., Oura, H., Nonaka, G., and Nishioka, I. Jiao DH, Ma YH, Chen SJ, et al. Native to Siberian alpine meadows, Rhaponticum ( Rhaponticum carthamoides) is a perennial herb that is commonly called maral root. By the end of the 19th century, it became clear that the particular medicinal characteristics of rhubarb were affected by conditions under which the roots grew, such as soil composition and climate.5, Rhubarb has been used medicinally in Europe since the 13th century. Rhubarb is sometimes applied to the skin to treat cold sores. Estroven says that their product is safe but provides no evidence to support these claims. In vitro binding of bile salt to rhubarb stalk powder. (Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579. Goel, V., Ooraikul, B., and Basu, T. K. Effect of dietary rhubarb stalk fiber on the bioavailability of calcium in rats. [Retention enema with Rheum decoction in treating renal failure]. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. Rhubarb use in patients treated with Kampo medicinea risk for gastric cancer? As a result, we recommend you get medical advice before taking it. How to handle headaches, night sweats, and more. Zhong.Xi.Yi.Jie.He.Za Zhi. If you already have kidney disease, don't risk making it worse by taking rhubarb. It is created by eHealthMe based on reports of 163 people who have side effects while taking Rhubarb from the FDA, and is updated regularly. Additional studies are needed to determine safety and effectiveness. Rhubarb resembles a celery stalk only it has a pale green or pink color and is sour to taste. Fu, D. C. and Yu, C. Y. Zhu, Y. Farnsworth N, Bingel A, Cordell G, et al. Clinical study on rhubarb extract tablet in treating simple obesity. Some medications for inflammation can decrease potassium in the body. J Tradit.Chin Med 1997;17(3):168-173. In most cases, rhubarb root side effects are associated with large dosages, especially those with longer durations. Yang, J. W. and Li, L. S. [Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat]. Use of this Web site does not create an expressed or implied physician-patient relationship. Li, C., Zhou, J., Gui, P., and He, X. Medically reviewed by Drugs.com. Common side effects may include: stomach pain or upset; heavy feeling; vaginal bleeding or spotting; Its most important active ingredients are the hydroxystilbenes (see stilbenes below) rhaponticin (fluoresces blue in UV light), rhapontigenin, deoxyrhapontigenin, substances with oestrogenic effects. Cultivating red-stalked rhubarb plants is an important source of raw materials for producing health-promoting foods. Is the ketogenic diet right for autoimmune conditions? Amberen and Estroven are two brands of over-the-counter supplement products. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Slideshow: 11 Supplements for Menopause Symptoms, Natural Treatments for Menopause Symptoms. Some medications can also harm the kidneys. The following doses have been studied in scientific research: You are encouraged to report negative side effects of prescription drugs to the FDA. Required fields are marked *. (Chinese Journal of Modern Developments in Traditional Medicine) 1988;8(6):344-6, 324-5. Zheng, F. [Effect of Rheum officinal on the proliferation of renal tubular cells in vitro]. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Over-the-counter medicines or . Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). 2010, 5:7. Ji, S. M., Li, L. S., and Ji, D. X. Evaluation of anti-inflammatory markers suggests that an anti-inflammatory action of rhubarb is responsible for the effect.18, In addition to the sennosides present in rhubarb extracts, which have been traditionally used as a laxative, emodin and other anthraquinones exert action on the GI tract. Both Amberen and Estroven claim that their products relieve various symptoms associated with menopause, such as hot flashes and mood changes. Vegetable stearic acid is going to enhance your energy levels and it is going to improve your overall health condition. The Diacerein Study Group. People who have liver problems should avoid rhubarb. A few studies have also been conducted using topical applications. A review. Studies in humans are limited, but suggest rhubarb can improve feeding tolerance and relieve gastrointestinal dysfunction in very ill patients. Anthraquinone extracts of rhubarb induced cytotoxicity in cancer cell lines(5) and tumor necrosis in mice(1), although this has not been demonstrated in humans. Chinese Rhubarb, Da Huang, Garden Rhubarb, Himalayan Rhubarb, Indian Rhubarb, Medicinal Rhubarb, Radix et Rhizoma Rhei, Rewandchini, Rhei, Rhei Radix, Rheum australe, Rheum emodi, Rheum officinale, Rheum palmatum, Rheum tanguticum, Rhubarbe, Rhubarbe de Chine, Rhubarbe Indienne, Rhubarbe Mdicinale, Rhubarbe Palme, Rhubarbe Potagre, Rhubarbe Turque, Ruibarbo, Tai Huang, Turkey Rhubarb. The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. View abstract. Stop using this product and call your doctor at once if you have signs of liver problems, such as: nausea, loss of appetite, upper stomach pain; itching, tired feeling; dark urine, clay-colored stools; or. 1998;18(12):712-714. The efficacy of ERr 731(), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Sun, Y., Chen, B., and Jia, Q. Offentl.Gesundheitswes. Taking rhubarb along with medication that might also harm the liver can increase the risk of liver damage. It's not entirely clear how ERr 731 performs its actions in the body, write the researchers. Both brands claim that their products provide numerous benefits: Amberen claims that their Multi-Symptom Menopause Relief product relieves 12 symptoms, including: The supplements come as capsules and help restore hormone balance. A Study has proved the favorable effects of stearic acid[3]. Researchers found a clear decrease in the number hot flashes and symptoms in women who had taken ERr 731. Additionally, rhubarb contains a healthy dose of fiber, which contributes to good digestion, absolutely necessary for healthy weight loss. Laxatives can decrease how much medicine your body absorbs. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. They say the results suggest ERr 731 may be a viable alternative treatment for women experiencing severe hot flashes associated with menopause and perimenopause. Design: Three hundred sixty-three menopausal women with menopausal . Negative reviews mention adverse side effects from the product. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. [Acute haemodyalysis-requiring kidney failure due to massive intake of rhubarb stew]. Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb Rheum rhaponticum L. high in rhaponticin) acts like a selective estrogen receptor modulator for ER receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. Oscaby, F. [A chlorhexidine-rhubarb extract mixture for gingival inflammation]. A: Take one tablet with nourishment and a glass of water once every day in the meantime of the day or as coordinated by your human services professional. Zhou, H. and Jiao, D. [312 cases of gastric and duodenal ulcer bleeding treated with 3 kinds of alcoholic extract rhubarb tablets]. The entire process of menopause lasts about 7 years for most people. Most reported clinical trials have been small and poorly designed, and in some studies, a number of different herbs were coadministered with rhubarb, making it difficult to evaluate which herb contributed to the outcomes. Zhonghua Fu Chan Ke.Za Zhi [Chinese Journal of Obstetrics and Gynecology] 1994;29(8):463-4, 509. [Clinical study on effect of Chinese herbal medicine combined with hemodialysis in treating uremia]. Taking rhubarb along with "water pills" might decrease potassium in the body too much. Study on low-dose of processed rhubarb in preventing pregnancy induced hypertension. *All individuals are unique. Additional studies to confirm safety and efficacy are needed. Zhonghua Yi.Xue.Za Zhi. The perennial herb has a conical rootstock, that is fleshy and yellow inside and produces large, cordate, 7-lobed leaves 30 to 46 cm long. Brinker F. Herb Contraindications and Drug Interactions. Another study showed that emodin inhibits human cancer cell invasiveness by specifically antagonizing the adenosine 5-triphosphate-gated Ca(2+)-permeable channel P2X7 receptor(17). Stay up to date with the latest health information from experts/contributors at Consumer Health Digest. It claims this product relieves 10 symptoms of perimenopause. View abstract. When used in small doses, the tannin content in rhubarb has a constipating effect. An anti-inflammatory action has also been suggested.22, Experiments in mice and rats receiving a cholesterol-enriched diet or with induced diabetic nephropathy/hyperlipidemia showed an improved lipid profile with rhubarb extract compared with control animals.23, 24, 25 Rabbits with induced atherosclerotic plaques and fed a high-cholesterol diet demonstrated a decrease in plaque rupture with either administration of rhubarb extract or simvastatin compared with control. J Am Coll.Nutr 1997;16(6):600-604. 1-30-1992;62(596):23-25. Rhubarb is a laxative. Zhongguo Zhong.Yao Za Zhi. View abstract. Rhubarb is a plant. ERr 731 is a standardized extract of Siberian rhubarb root, a plant-derived, nonhormonal therapy designed to alleviate menopausal symptoms, including hot flashes. View abstract. Research shows evidence for the effectiveness of this plant in treating menopause symptoms. About half of the women took a tablet containing 4 milligrams of the rhubarb extract and the other half received a placebo for 12 weeks. Some people use rhubarb so they have to strain less during bowel movements; this reduces pain from hemorrhoids or tears in the skin lining the anal canal (anal fissures). View abstract. The dry extract from the roots of rhapontic rhubarb (Rheum rhaponticum) belongs to the group of phytopharmaceuticals. Zhu, W., Wang, X. M., Zhang, L., Li, X. Y., and Wang, B. X. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. By age 54, I had tried HRT and every supplement out there. A meta-analysis suggests that rhubarb adjuvant to early enteral nutrition may benefit patients with severe acute pancreatitis(35), but a systematic review does not support its use for gastrointestinal failure in ICU patients(36). Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Pharmacology 1976;14:48-61. Its active ingredient is rhapontic rhubarb extract. Symptoms associated with perimenopause generally subside postmenopause. There is a report of kidney failure in someone who took a product containing rhubarb. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Menofit is a probiotic supplement. Rhubarb has various health benefits and one of them is its ability to inhibit and treat infections like cold sores. Estroven should not be taken without guidance from a healthcare provider. 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