This is because the drugs could be passed to the baby through breast milk. But you are unlikely to lose all the hair from your head. If you have an intolerance to lactose, contact your doctor before taking this medicine. You are taking steps to ensure your father gets the best treatment. After your treatment is over, most side effects start to improve. Good luck with the rest of your treatment. The cold sensitivity is pretty bad for me. On the other hand, Epirubicin, Cisplatin plus continuous infusion of 5-FU is widely used as a palliative regimen in patients with gastric cancer. These side effects happen in more than 10 in 100 people (more than 10%). It is easier to prevent sickness rather than treating it once it has started. Each cycle lasts 3 weeks (21 days). If you have DPD deficiency, this can affect the treatments that are available for you. Actually, I feel pretty good. If you have a stoma, it will be more active than usual. A lot of it may just be luck or makeup, things not in our control, but mindset and determination are also a big part of all of this. The main problems I've had was the Peripheral Neuropathy which started near the end of my treatment. Platelets are cells that help the blood to clot. Repeat every 21 days for 8 cycles for high-risk stage III colon cancer (any T4 and . A low white blood cell count is sometimes called neutropenia. Tell your doctor if you develop: You should also tell them if any existing breathing problems get worse. Sometimes a reaction happens a few hours after treatment. Take the drugs exactly as your nurse or pharmacist tells you. Your oncologist or the financial counsel at your CA center should have info on these. Chewing gum can help to keep the mouth moist. Thats a very annoying side effect. This can be a: You mighthave treatmentthrough a thin short tube (a cannula) that goes into a vein in your arm. Like JJ I had Folfox. This treatment may make your eyes feel sore, red and itchy (conjunctivitis). I second what everyone said about keeping your hands and feet warm while on the oxaliplatin. So far as is permitted by law, Macmillan does not accept liability in relation to the use of any information contained in this publication or third party information or websites included or referred to in it. Macmillan Cancer Support 2020 Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). The second year my mum had the same combination they had to reduce her dose for other reasons but the upside was a significant reduction in her side effects with only a minimal reduction in strength . I once got a huge blister at the gym and couldn't use the treadmill for a couple of weeks. This means they will be more likely to work for you. You couldlose all your hair. Welcome back to the forum . I was on both plus Avastin for 6 treatments (later on just Xeloda and Avastin). Babies have the live rotavirus vaccine. Tell your doctor or nurse about any changes to your hands or feet. If you need to talk, we'll listen. I'm also new here. Try to pace yourself and plan your day so you have time to rest. Glad your comfortable with your decision. Eat less fibre, avoid raw fruits, fruit juice, cereals and vegetables, and drink plentyto replace the fluid lost. This treatment may cause headaches. Find out about the emotional, physical and practical effects of cancer and how to manage them. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Talk to your doctor if you are worried about this. You may not be able to become pregnant or father a child after treatment with thesedrugs. If the number of platelets is low, you may bruise or bleed easily. The number of white blood cells will usually return to normal before your next treatment. Back and can add some more Not sure if you read my profile. FOLFOX Protocol V1.2. It is important to tell your doctor or nurse if you have a cough or are breathless. They will talk to you about your blood results and ask you how you have been feeling. Sickness, taste changes or tiredness can put you off food and drinks. Its a horrible condition . XE or CAP - capecitabine (Xeloda ) OX - oxaliplatin. avoid alcohol, tobacco, and foods that irritate your mouth and throat. During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. The significant symptoms of cholangiocarcinoma includes jaundice, weight reduction, loss of hunger, blood in stool and urine, stomach pain, fever, and itching. Accessing the HOPE course through Macmillan Wellsprings story. Or less commonly you may lose weight. Sometimes it can cause areas of your skin to darken. It is also known as colorectal cancer. The global cholangiocarcinoma market is estimated to be valued at US$ 185.4 million in 2021 and is expected to exhibit a CAGR of 12.8 % during the forecast period (2021-2028). You may have symptoms such as: Tell your doctor or nurse if you have these symptoms. Physicians . These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. I wish I could remember the threads from about a year and a half ago. I wear slippers around the house, and a big sweater. I don't know if you'll be able to find them now that winter is over. But for some people they may never go away. An infection can be very serious when the number of white blood cells is low. If you develop any signs or feel unwell after you get home, contact the hospital straight away. Your doctor will prescribe eye drops to help prevent this. Swallow them whole with a glass of water within half an hour of eating a meal. If you are sick just after taking the tablets, contact the hospital. Your nurse willtell you what products you can use on your skin to help. I only took off infusion day and worked and worked out the rest of the time. And today I learned my "copay" for two weeks of capecitabine is just short of $1,100USD. a short thin tube the nurse puts into a vein in your arm or hand (, a fine tube that goes under the skin of your chest and into a vein close by (, a fine tube that is put into a vein in your arm and goes up into a vein in your chest (. Isle of Man company number 4694F. Affiliation 1 . Rarely you might be unable to control when you pass urine, fluid build up in different parts of the body, low levels of fluid in the body (dehydration), liver problems that are picked up on blood tests, rarely you might have yellowing of the skin and whites of the eyes, numbness and tingling sensation on the skin can make it difficult to do fiddly things such as doing up buttons (peripheral neuropathy), inflammation of the membranes covering the brain and spinal cord (meninges) causing symptoms similar to meningitis such as stiff neck, headaches and unable to look at bright light, swelling of the nerves to your muscles, this can cause problems with moving your body causing weakness, clumsiness, loss of balance and falls, a sudden feeling of being hot and your skin going red (flushing), ear problems such as hearing loss and rarely you might pain in your ears and unable to hear, heart problems such as changes to heartrate or rhythm, angina or a heart attack, severe skin reaction that may start as tender red patches which leads to peeling or blistering of the skin. This can cause difficulties with swallowing and breathing. You may have: Tell your doctor if you have any unexplained bruising or bleeding. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae). Treatment options are often the same for both stage 4 and recurrent rectal cancer. Try to take gentle exercise, such as walking. Gentle exercise, like short walks, can give you more energy. I'd come home from chemo with my fingers tingling, but not really painful. your temperature goes over 37.5C (99.5F), you suddenly feel unwell, even with a normal temperature. I was on the 2 week on/1 week off Xeloda plan with oxalilatin every 3 weeks. Very rarely, capecitabine may cause a more serious skin condition. I usually feel a bit off (mostly low energy) for a week - week and a half, then I feel good for a week and a half - two weeks. Your doctor or nurse may talk to you about having vaccinations. If your blood results are okay, the pharmacist will prepare your chemotherapy. A reaction may happen during the infusion, causing a skin rash, itching, swelling of the lips, face or throat, breathing difficulties, fever and chills. Side effects while treatment is being given. Capecitabine contains lactose (milk sugar). They sometimes need to lower the dose of the drug. INTRODUCTION; REGIMENS. I had to quit my job due to my chemo therapy. Not the same chemo but I had severe pains in my joints all over my body also in my legs and feet. Less commonly you might have a dry mouth. avoid alcohol, caffeine, milk products, high-fat foods and high-fibre foods. the anti-diarrhoea drugs do not work within 24 hours. I hope it's the same for you! Find out about support groups, where to get information and how to get involved with Macmillan where you live. All had . Let your healthcare team know straight away if you have any bleeding. They include: Numbness or tingling in fingers or toesis often temporary and can improve after youfinish treatment. You may find it hard to fasten buttons or do other fiddly tasks. Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. You might have other symptoms depending on where the infection is. Talk to your doctor or nurse about effective contraception before starting treatment. Taste changesusually get better after treatment finishes. Make sure to hang out and ask questions during all of this, you got this man. It may grow backa different colour or be curlier than before. The glass and spoon should be washed and kept separate from your other crockery and cooking utensils. Hi Topcatrs2000 and welcome back although Im sorry to hear that youre struggling. I also have been left with painful feet which I did mention but not until after all my chemo had finished! First published: March 2013 and regularly updated on the Gov.UK website, Handbook of Cancer Chemotherapy (8th edition) This is to make sure they work as well as possible for you. This treatment may cause hearing changes, including hearing loss. Oxaliplatin can cause pain at the place where the injection is given or along the vein. Wash your hands after taking your tablets and capsules. One former member used to drink cold water while being infused with the oxy and it prevented a lot of the cold issues. Good luck with the rest of your treatment. You may get pain or discomfort in your tummy (abdomen). For colorectal cancer: But some can be permanent. I hope that you will hear from some of our members' experiences of these chemo tablets. wrap up warm and cover your nose and mouth in cold weather. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . I'm on Xeloda right now and have been on it for a week and have had no side effects at all. You may also have tingling, numbness, pain and dryness. Rarely, oxaliplatin can cause a spasm in the throat area around the voicebox (larynx). Tell your doctor or nurse if you are finding it difficult to control your weight. court over 3 years ago. Your nurse will give you medicines beforehand to try to prevent a reaction. sometime have programs to help with the cost. If you have breathing difficulties, take long, deep breaths through your nose. ** Capecitabine is available as 150 mg and 500 mg tablets (refer to . Quite a few members of our forum have taken Capecitabine, for example @Cutie mentions it on this thread . You have oxaliplatin as a drip into your bloodstream over 2 hours. It is not a substitute for professional medical advice. Based on the gene mutation profile, the patient received the bevacizumab-oxaliplatin regime and then the bevacizumab-capecitabine as maintenance treatment. Progression-free survival and response rates did not differ significantly among the regimens. If you feel sleepy, do not drive or use machinery. Methods: mEOC/GOG 241 is a multi-centre randomised phase II trial (UK, USA) in chemo- naive pts with advanced/recurrent . Tell your doctor or nurse if you have ulcers. This is because they can make you unwell. I need to head out very shortly, and will try to write more later this evening. Capecitabine can affect how the heart works. Your cancer doctor or GP can tell you more about live and inactivated vaccinations. Your doctor will advise you not to get pregnant or make someone pregnant while having this treatment. Your doctor will tell you the amount (dose) of capecitabine you need to take. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. Abstract. You take capecitabine tablets twice a day. They may give you painkillers to help. If you cannot get through to your doctor, call the NHS urgent advice number which is 111. Signs of a severe skin reaction include peeling or blistering of the skin. This can happen whilst you have oxaliplatin or within a few hours of it finishing. This is called a blood transfusion. Depending on your needs, you may have between 4 and 8 cycles. It is still possible for the heart to be affected even if these test results are normal. Donate today to help people with cancer live life as fully as they can. It usually gets better after treatment ends. It is important to use these as you are told to. Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. The oxy caused this weird cold sensitivity and "first bite" syndrome - temporarily feeling like there were glass shard in your throat - but very temporary. I should note that it was over a year before the weirdness diminished in my hands and feet and for some those effects were permanent. Oxaliplatin forms crosslinks that inhibit DNA replication and transcription, resulting in cell death in actively dividing cells. Most people get it along with Xeloda. You will see a doctor or nurse before you have chemotherapy. Men might be able tostore spermbefore starting treatment. No matter how bad I felt- and believe me, I felt bad - I always got out of bed. However, there has only been experience in Japanese patients with using CapOX therapy, in which capecitabine and oxaliplatin are used in . The content on this site is for informational purposes only. I guess that makes me T3 N1b M0. I'm a contractor and to keep working was a necessity, but I believe it kept my focus off how every little thing felt, and helped my body pump it through, if that makes any sense. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle for a maximum of 8 cycles. It is also important to empty your bladder regularly and to try to pass urine as soon as you feel the need to go. We also include some less common side effects. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. The oxilaplatin causes neuropathy and cold sensitivity. When the diarrhoea is better, they will tell you if you can start taking it again. After that you have a rest period with no treatment for 7 days. For colorectal cancer: but some can be permanent sometimes it can cause a spasm in the area. On where the infection is want to chat to your doctor if you read my profile is over of! 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